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49ers host the Panthers in a matchup of NFC playoff contenders
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San Francisco 49ers running back Christian McCaffrey, middle, runs toward the end zone to score against the Arizona Cardinals during the second half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. - photo by AP Photo/Rick Scuteri
Carolina (6-5) at San Francisco (7-4) Monday, 8:15 p.m. EST, ESPN BetMGM NFL Odds: 49ers by 7 Against the spread: Rams 7-4, 49ers 6-5 Series record: Panthers lead 13-10. Last meeting: 49ers beat Panthers 37-15, in Charlotte, N.C., on Oct. 9, 2022. Last week: Panthers beat Falcons 30-27 in OT; 49ers beat Cardinals 41-22.