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Cardinals and 49ers face off in Week 3 matchup of undefeated teams
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Arizona Cardinals linebacker Josh Sweat (10) forces Carolina Panthers quarterback Bryce Young (9) to fumble during the first half of an NFL football game, Sunday, Sept. 14, 2025, in Glendale, Ariz. - photo by AP Photo/Rick Scuteri
Arizona (2-0) at San Francisco (2-0) Sunday, 4:25 p.m. EDT, Fox. BetMGM NFL Odds: 49ers by 2 1/2. Against the spread: Cardinals 1-1; 49ers 2-0.